死亡笔记

一 |     A team of scientists has discovered a likely explanation for why one may feel exhausted after engaging in intense cognitive work.,In their study, published in the Current Biology last week, the researchers argue that intense cognitive work, when it lasts for several hours, results in the buildup of potentially toxic byproducts in the prefrontal cortex part of the human brain, which then affects a person’s behavior.,“Influential theories suggested that fatigue is a sort of illusion cooked up by the brain to make us stop whatever we are doing and turn to a more gratifying activity,” Mathias Pessiglione of Pitié-Salpêtrière University in Paris, said as quoted in a news release by Cell Press. “But our findings show that cognitive work results in a true functional alteration—accumulation of noxious substances—so fatigue would indeed be a signal that makes us stop working but for a different purpose: to preserve the integrity of brain functioning.”,During the course of their research, the team employed magnetic resonance spectroscopy to monitor the brain chemistry of two groups of people during a workday, with one group performing easy cognitive tasks while the other engaged in more complex mental activities.,Only the latter group ended up exhibiting signs of fatigue, as well as a tendency to favor “options proposing rewards at short delay with little effort,” as the news release put it.,AmericasChild Survives After 7 Minutes Without Blood Flow to Brain During Surgery, US Cardiologist Reveals11 August, 16:41 GMT,Furthermore, members of that group had higher levels of glutamate in the synapses of the prefrontal cortex, leading the researchers to suggest that the accumulation of glutamate “makes further activation of the prefrontal cortex more costly,” and thus a mentally exhaustive workday makes cognitive control more difficult.,Unfortunately, there seems to be no fancy way to deal with this problem other than the tried and tested method that is probably as old as history itself.,“I would employ good old recipes: rest and sleep!” Pessiglione remarked. “There is good evidence that glutamate is eliminated from synapses during sleep.”。

二 |     任天堂公布了首批 Switch 2 主机套装，这批套装将在主机即将涨价后发售。届时将提供两种选择，购买包含 Mario Kart World 或 Nintendo Switch Sports Resort 的套装可享受折扣。

三 | 提醒一下，Switch 2 即将在 5 天内上调美国、加拿大、英国和欧洲大陆地区的售价，这意味着在涨价前按首发原价购买的时间已经不多了。在美国，Switch 2 的价格将上涨 50 美元，达到 499.99 美元。从“9 月下旬”开始，任天堂将再次推出包含首发游戏 Mario Kart World 和三个月 Nintendo Switch Online 会员的 Switch 2 套装。

四 | 该套装售价为 549.99 美元，任天堂表示这节省了 37.98 美元。接着，从 10 月 22 日起，随着 Nintendo Switch Sports Resort 的发售，第二个套装选项也将上市。包含游戏、主机以及 90 天 Nintendo Switch Online 订阅的套装售价为 529.99 美元。

五 | 任天堂表示，这节省了 27.98 美元。虽然为潜在的 Switch 2 买家提供省钱的新选择是件好事，但值得强调的是，如果你能在未来几天内买到主机和 Mario Kart World，省下的钱会更多。除此之外，那些正在寻找更别致主机设计的玩家，可能会被本月早些时候在网上流传的《塞尔达传说》40 周年纪念版 Nintendo Switch 2 主机和 Pro 手柄的泄露图所吸引。不过，目前还不知道这些产品的售价。在任天堂的 Zelda: Ocarina of Time remake 于年底前发布之前，我们很可能会很快看到这些产品的官方消息。任天堂最初在 5 月份确认将上调 Switch 2 的价格，确保客户在价格上涨生效前有几个月的预警期。当时，该公司对涨价的必要性表示歉意，并将变动归因于“市场环境”，并表示被迫考虑“全球业务前景”。当然，Switch 2 的涨价只是硬件厂商上调价格的最新案例。

六 | 面对全球航运、关税的不确定性以及组件价格的飙升，PlayStation、Xbox 和 Valve 在过去一年里都上调了价格。

七 | 那么，现在是你入手 Switch 2 的好时机吗？。

八 |